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KMID : 0363319980190010452
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Journal of Korean Oriental Internal Medicine
1998 Volume.19 No. 1 p.452 ~ p.465
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Effect of the Rosae laevigatae Fructus extract on the nitric oxide synthase activity and antioxidan action in Rat’s corpus cavernosum penis
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Kim Kyung-Dong
Jung Ji-Chun
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Abstract
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Rosae laevigatae Fructus extract (RLF) was tested for the effects on the urethral nitric oxide synthase (NOS) activity and Antioxidation in streptozotocin (STZ) induced diabetic rats. RLF was treated firstly into samples, and then STZ induced diabetic rats were set with them. In vitro, the urethral NOS activity was not noted but the type O activity and type conversion ratio of xanthine oxidase and the level of urethral lipid peroxide were decreased in the level of Dose of extract prepared from RLF. In vivo, after the extract was administered to the animal model for fifteen days, the urethral NOS activity increased in STZ induced diabetic rats to the level of normal rats. The content of urethral nitrite and glutathione followed by RLF pre-medicating administration, increased as highly as normal group in compare with the group treated with STZ. The type O activity and type conversion ratio of xanthine oxidase and the level of urethral lipid peroxide followed by RLF pre-medicating administration, decreased as lowly as normal group in compare with the group treated with STZ. In conclusion, the extract of RLF will be able to restore erectile dysfunction of STZ induced diabetic rats.
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KEYWORD
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Rosae laevigatae Fructus, nitric oxide synthase, nitrite, lipid peroxide, xanthine oxidase, erectile dysfunction
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